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Google DeepMind Publishes AI-Powered Predictions For Effect of All 9 Billion Mutations to Human DNA

Google DeepMind has released AlphaGenome Atlas, a free research database containing AI-generated predictions for the effects of all 9 billion possible single-letter mutations in the human genome. Built from its AlphaGenome model, the atlas is designed to help scientists interpret both protein-coding and harder-to-understand regulatory DNA. Fortune reports: AlphaGenome Atlas, as DeepMind calls the database, is a precomputed catalogue of what each substitution of a single DNA base is likely to do to the machinery that switches genes on and off. Until now researchers had to run such a model one variant at a time or had to test variants in the laboratory, a process that was painstakingly slow. It would have taken many human lifetimes to discover the consequences of all 9 billion possible single-letter mutations. The Atlas promises to make the job of biologists and medical researchers considerably easier, potentially speeding up the understanding of genetic diseases and the hunt for possible cures. Pushmeet Kohli, DeepMind's vice president for research and head of its AI for science team, told reporters on a briefing call that this was the first time any researcher in the world could reach a comprehensive map of human genetic variation "by simply opening a browser." Kohli also framed the release as helping to complete the unfinished business of the Human Genome Project, which in 2003 succeeded in mapping the entire human DNA sequence. "As the saying goes, we bought the book," he said, "but we did not understand how to read it." Atlas is available for non-commercial use from today through a website Google DeepMind has set up for it. The company said it would be available for commercial use through a licensing arrangement through Google Cloud "soon." Kohli said that Google DeepMind's sister company,ÂIsomorphic Labs, which is using AI for drug discovery, would have access to Atlas but that it would also require a commercial license for access. He did not specify exactly what the terms would be for commercial licensing. A paper describing the Atlas and how it was created is being released on bioRxiv, a repository for biomedical preprint academic papers.

Read more of this story at Slashdot.

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Forget folding screens, Apple is working on stretchable ones

New research that suggests that future iPhones, iPads, or perhaps Apple Watches could have a stretchable display on the outside, instead of one that just folds inward. Here's how Apple plans to do it.

Cross-sectional technical diagram of a dome-shaped electronic device component with multiple labeled parts and layers, viewed on a tablet screen.
An iPad showing one illustration of a stretchable disolay

For years now, Apple has been expected to produce a folding screen iPhone, and that's more than likely to appear at the September 9, 2026 event. But all along, at lease 50 Apple engineers have been working instead on stretchable displays.

That's how many are credited on the newly-granted patent that's just called "Stretchable Display." It's at least five times more than are normally credited on an Apple patent, and so this is a serious and longterm commitment by Apple.


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What to expect from Apple's 'Surprise and shine' iPhone 18 Pro event on September 9

Apple has confirmed its September special event will be held on September 9. It won't just be the iPhone 18 Pro or folding iPhone launch, but also the first event with John Ternus as CEO. Here's what to expect.

Glowing white Apple logo with a bite on the right, centered on a soft blue background with light halo and subtle rainbow-like highlights
The Apple logo accompanying the 2026 event invite

Regular as clockwork, Apple holds an event in early September to launch new iPhone models and other products. Apple has just confirmed that this will be the case for 2026's presentation.

Titled "Surprise and shine," the event will be taking place on September 9, starting at 10 A.M. Pacific, 1 P.M. Eastern Time. As usual, it will be streamed on YouTube, the Apple Event page, and the Apple TV app, among other methods.


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Slim Spider Steals Crypto Custody Secrets From Brazilian Financial Institution

A previously undocumented financially motivated threat actor has been linked to attacks targeting Brazilian financial institutions since at least March 2026. Cybersecurity company CrowdStrike is tracking the Brazil-based activity cluster under the name Slim Spider. "The adversary demonstrates deep operational knowledge of Brazilian financial infrastructure, including the instant payment

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Experiencias en multinacionales

Si has trabajado en multinacionales o trabajas en una, compartirías cómo fue tu proceso de reclutamiento cuando entraste? Ya sea Dell, grainger, Phillips, etc.

Hicieron pruebas psicológicas, cuantas entrevistas? Cuánto fue el tiempo promedio entre el primer correo de la empresa hasta que firmaron contrato?

Solo por curiosidad y para que muchos que tenemos esa pregunta, la tengamos presente con respuestas, muchas gracias!

submitted by /u/JuanJosex98 to r/Panama
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where’s your line between “please manage Drupal for me” and “give me access to the code”?

the Webflow Source announcement sent me back into Acquia’s Source CMS product guide.

it explicitly says "customers can’t modify the underlying Drupal code or install contributed modules".

I understand the deal: less maintenance responsibility, fewer opportunities to make a beautifully customized disaster.

buttttt Drupal’s flexibility is also why a lot of people chose it.

where does that tradeoff work for you?

for a straightforward marketing site, I can see the appeal. for a project with specific integration or editorial requirements, I’d want to know where the escape hatches are.

what’s the requirement that would make you say “managed SaaS is fine”... or immediately ask for the keys?

I covered the two Sources on my Headless show, but this is the part I’d rather hear from people building and maintaining Drupal sites.

submitted by /u/Aggressive_Trip_4872 to r/drupal
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BBC breakout comedy 'Small Prophets' is coming back for season two

After a strong first season, and an Apple TV pickup, BBC comedy "Small Prophets" is returning for a second season and making the jump from BBC Two to BBC One.

Elderly man with long gray hair and beard carefully pouring water from a large metal bucket into a smaller container inside a warmly lit, cluttered, rustic room
Pearce Quigley stars as a man driven to alchemy as he searches for his long-missing partner in "Small Prophets" - image credit: BBC

The move to BBC One puts "Small Prophets" in front of a larger audience after its first season became the BBC's biggest new comedy of the year. The series debuted on BBC Two in February and has been compared to "Ted Lasso."

Season one follows Michael Sleep, whose partner Clea disappeared nearly a decade ago. An average man, Sleep's days are spent working in a DIY store, visiting his father, and hoping for Clea's return.


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Teen Reading Slumps to Worst This Century Due to Surge in Screen Time

Teen reading, math, and science scores have fallen to their lowest levels since international PISA testing began in 2000, with 15-year-olds now reading at roughly the level previously expected of students a year younger. The Organization for Economic Co-operation and Development (OECD) linked weaker results to more screen time, less reading for pleasure, and digital distraction. It also found that students who regularly used AI chatbots for tasks like drafting essays and summarizing text scored about 20 points lower in science, roughly equivalent to a year of learning. Reuters reports: A 2012 reading high of 501 on PISA's index had declined to a score of 466 last year. The test is widely regarded as the world's leading gauge of educational performance and its results are closely scrutinized by governments and educators. "In reading, more screen time and less reading for pleasure have gone hand in hand with weaker results," OECD head Mathias Cormann told a press conference. "We're also seeing more hasty reading, students rushing through a text and giving a quick wrong answer." Reading scores fell more sharply in students from better-off backgrounds, the study added. Hindered by falling reading standards, average teenage science and maths skills were also at their lowest this century. Science fell from a 2009 high of 506 on the index to 486, while maths was down from 502 to 469 in the same period. East Asia was the best-performing region. Chinese cities that participated in the test, Japan, Korea, Singapore and Taiwan had the best educational systems with Britain and Estonia the only countries outside the region that made it into the top 10 in reading, mathematics and science.

Read more of this story at Slashdot.

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A Foco se le puede considerar lolcows del "periodismo" panameño?

Se me acaba de ocurrir esa pregunta bien random, en base a controversias que han tenido últimamente, como intentar joder convenciones de anime. Qué dicen ustedes?

submitted by /u/Agreeable-Crew4355 to r/Panama
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GitHub - orange-groove/react-map-annotate: Draw on Mapbox, MapLibre, Google, Leaflet, or ArcGIS in React

GitHub - orange-groove/react-map-annotate: Draw on Mapbox, MapLibre, Google, Leaflet, or ArcGIS in React

I built an open-source React map drawing library because I got tired of fighting drawing controls that wanted to own the UI.

react-map-annotate lets your application control the drawing session. Put the toolbar in your sidebar, header, or command palette. Select tools, finish shapes, edit labels and colors, undo/redo, and persist annotations through React state.

It supports Mapbox, MapLibre, Google Maps, Leaflet, and ArcGIS through separate adapters, with a shared annotation model.

The goal is simple: the map should render the drawing, not dictate how your application works.

It includes freehand drawing, polygons, rectangles, circles, arrows, markers, text, and measurement tools, along with editing handles and a headless API.

The project is MIT licensed and available on npm. I’d love feedback from developers building GIS, field-service, site-planning, or other map-heavy applications—especially anyone who has had to work around existing drawing controls.

GitHub: https://github.com/orange-groove/react-map-annotate

npm: https://www.npmjs.com/package/@orange-groove/react-map-annotate

What would you need from a drawing library before using it in a production application?

submitted by /u/Silly-Calligrapher21 to r/reactjs
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Más bombo le están dando a la designación de la ADMINSITRADORA DEL CANAL.

Más bombo le están dando a la designación de la ADMINSITRADORA DEL CANAL.

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"La primera mujer en ocupar la administración del Canal"... ok, es cierto ¿y qué con eso?. ¿Todavía es un tabú estas cosas? ¿Era imposible? ¿Había alguna restricción? ¿estamos en los años 1900?

Muchas veces la misma opinión pública (periodistas, abogados, presentadores, etc) se encargan de estigmatizar a la mujer con supuestos halagos y cumplidos, creyendo que con eso están ayudando a una causa.

Hay gente que maquinan una película de que existe una lucha de género, y que la mujer constantemente tiene que estar demostrando de que es tan capaz como un hombre y superarlo...incluso han mencionado esa frase: "las mujeres son tan capaces como un hombre"... detrás de estos supuestos halagos y afirmaciones hay un complejo del que lo dice: Realmente no se lo cree, pero lo dice tantas veces solo para hacer sentir bien a un sector (en su interior reconoce que existe una inferioridad). La comparación en si misma ya crea una brecha, la crea y la perpetúa como si dieran por hecho de que es una batalla entre David y Goliath y que se extenderá hasta el final de los tiempos.

¿No se cansan de todo esto?. Muchas veces no vemos tantas mujeres ejerciendo en puestos especificos smplemente porque a ellas mismas no les interesa, no porque se lo prohiban o porque se haya un plan para que tengan muchos más obstaculos que un hombre.

Esto de la Administradora del Canal debió ser informado como una simple transición más, no haciendo enfásis de que es un logro de género.

submitted by /u/Top-Bed6440 to r/Panama
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¿Reducir las 8 horas de trabajo?

He estado viendo varios posts sobre este tipo de comentarios y la verdad sí sería bastante obvio hacerlo, pero eso va a depender mucho de la persona que eres: responsable, no hacer el juega vivo y realizar tus tareas durante el día.

Mi padre tiene una empresa de jardinería a la cual obviamente él les paga a los trabajadores un salario un poquito debajo del salario mínimo, pero ellos mantienen su transporte (auto que los busca y los lleva).

El horario del contrato es de 7:00 AM a 4:00 PM, pero este horario no se cumple, ya que se trabaja por tareas (en este caso sí se aplica trabajar así). Entonces, si ellos terminan sus labores exitosamente, supongamos que a la 1:00 PM, ellos pueden irse normal para su casa.

En caso tal de que ellos hagan las cosas mal, no está permitido irse. ¿Cómo se supervisa eso? Obviamente, en la siguiente visita vemos todo eso y se les regaña o se les dice que quiero eso bien y que no pueden irse temprano.

Hay muchas veces que ellos van a su punto de trabajo y son las 11:00 AM, estoy en el lugar y si todo está bien, a las 12:00-1:00 PM están en su casa.

Y eso es calidad de vida. Ellos hacen sus trabajos pequeños por fuera que les da algo más de ingreso, SIEMPRE Y CUANDO no afecte mi círculo de clientes y trabajo.

Ahora, en mi caso, yo trabajo en el área de tecnología, la cual se puede hacer el trabajo de manera virtual. Sí, es posible, pero hay otras veces en que mediante una llamada no se pueda resolver una duda o no tenga un equipo para realizar el trabajo.

Entonces yo hablé con mi jefa y le dije: ¿por qué nosotros no nos colocamos 2 días en oficina y, si terminamos nuestro trabajo listo a las 2-3 de la tarde, dejarnos ir sin atarnos a un horario de salida? Y 3 en casa (sábado si es virtual).

Esto porque en momentos he llegado a ir a la oficina a calentar silla. He estado 4-5 días sin hacer nada y yendo a la oficina solamente a registrar asistencia.

Y me dirán: ¿por qué no investigas o aprendes algo más?

Obviamente lo hago y he propuesto ciertos sistemas que ayudan, pero prácticamente madrugar para ir a tu puesto a hacer NADA es más cansón que trabajar.

En resumen, ¿en el área de tecnología se puede reducir horas de trabajo?

Sí, siempre y cuando el puesto que tengas se pueda hacer.

¿Aplican todos a reducir horas o ser flexibles en el turno?

Sí, siempre y cuando tú seas una persona responsable, que no estés para hacerte el huevón en la casa o hacerte el vivo de no hacer nada.

¿Qué áreas es difícil bajar horas de trabajo?

Trabajos en el mall: cajeras, vendedoras, seguridad, pilotos, taxis, piratas u otras similares.

Ahora, ¿qué harías tú para proponerle a una empresa/jefe que esto sí puede hacerse cuando tú hayas demostrado que eres responsable en tu puesto?

Edit: He visto otros departamentos que el horario es a las 8:00 AM, llegan a las 9:00, "favoritismo", y encima de eso se ponen a desayunar y se van temprano

submitted by /u/Sea_Structure4178 to r/Panama
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I built a Laravel package to replay Stripe billing lifecycles offline

I built Cashier Dunning because testing failed-payment flows in Laravel is surprisingly difficult.

It records a real Stripe billing lifecycle once and replays it offline through your application's actual webhook route, including signature verification and real listeners.

It can replay trial expiration, failed payments, retries, cancellation and resubscription in about a second.

It also tests duplicate and out-of-order webhook delivery.

No Stripe account, API keys in CI, or network access during replay.

It's MIT licensed and currently supports Laravel 11–13.

GitHub: https://github.com/impruthvi/cashier-dunning

I'd especially appreciate feedback from anyone running Stripe/Cashier in production. What billing edge cases would you want something like this to test?

submitted by /u/impruthvi to r/PHP
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Secretive DHS 'Predictive Policing' Unit Is Analyzing Americans' Financial Habits, Pulling Them Over

An anonymous reader quotes a report from 404 Media: Border Patrol is running secretive predictive policing units that analyze Americans' financial activity and other data, then feed that intelligence to local police who pull people over who are not suspected of any specific crime, but which the government thinks may be worth searching, 404 Media has found. The units, the name of which 404 Media is revealing here for the first time, are called Predictive Intelligence Targeting Teams (PITT). In one case, a PITT analyzed the financial activity of a man who was driving across Montana, and local authorities stopped him under the pretense of an obstructed license plate and charged him with a DUI. 404 Media identified one PITT in the Spokane Sector, Washington, which polices the U.S. border with Canada, and another in the Laredo Sector, Texas, which polices the border with Mexico. The findings add to an Associated Press investigation from last year which found Border Patrol was using automatic license plate readers (ALPRs) as part of the same wide-spanning predictive policing program. "The bottom line is genuine probable cause cannot be synthetically generated," Jake Laperruque, deputy director of the Security and Surveillance Project at the Center For Democracy & Technology, told 404 Media in an email. Here Border Patrol seems to be "using parallel construction to cloak the reason behind its car stops in secrecy. If we can't meaningfully review and evaluate these systems, we can't trust them," he added. [...] The DHS document obtained by 404 Media shows that Border Patrol is analyzing the financial activity of Americans to find people to pull over. The Associated Press's investigation found the predictive policing program is also heavily using ALPRs to track potential targets' movements. It is not clear how exactly Border Patrol is monitoring Americans' financial activity. Customs and Border Protection (CBP) declined to answer what financial activity the agency was monitoring, and whether it obtained a warrant or not. A CBP spokesperson told 404 Media in an email: "U.S. Border Patrol uses intelligence-informed analysis and planning to support national security operations, allocate resources, and help identify potential threats and bad actors to public safety. These efforts are conducted consistent with applicable law, policy, privacy protections, and oversight requirements." The statement continued: "For operational security reasons, we do not discuss specific analytical methods, data sources, targeting criteria, investigative techniques, system capabilities, or deployment details. Public disclosure of such information could compromise law enforcement operations and investigations as well as creating safety risks for agents and the public." Rob Frommer, senior attorney at the Institute for Justice, told 404 Media: "The government's increasing use of mass surveillance -- whether that surveillance comes via ALPRs, financial records, or the like -- coupled with predictive policing is a recipe for tyranny. We fought a revolution for the idea that we are citizens, not subjects. Yet schemes like CBP's Predictive Intelligence Targeting Team treat all Americans as if they are potential suspects. This is not just wrong, it's unconstitutional, and IJ will keep pushing courts and Congress to end this attack on Americans' security."

Read more of this story at Slashdot.

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Liquid Hackers Return 3,400 Bitcoin Taken via Elements Bug, Still Holding $47M in BTC

Whoever took nearly 4,000 bitcoin from the Liquid Network on Sunday, September 6, returned 3,400 of it the next day, Bitcoin's public record shows. About 598.5 bitcoin has not come back. Liquid is a Bitcoin sidechain that holds real bitcoin to back a token called L-BTC. The network is still paused, so holders cannot turn that token back into bitcoin. The 3,400 bitcoin was sent to a&

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ChatGPT Flaw Let a Planted Prompt Send a Victim's Gmail Data to Another Account

Check Point Research said in a report published today that a single instruction planted in a ChatGPT conversation could cause ChatGPT to quietly work for an attacker while answering the user's question as usual. In the company's proof of concept, that hidden work read data from the user's connected Gmail account and passed it to a second ChatGPT account through a hidden channel

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Autonomous AI Agents Compromise Thousands of Credentials in Under Six Hours

Threat actors are continuing to leverage artificial intelligence (AI) to streamline their operations, with one financially motivated hacking group employing an autonomous, multi-agent attack framework to carry out a large-scale credential harvesting campaign within six hours. Google Threat Intelligence Group (GTIG) said it has observed attackers with diverse motivations targeting proprietary AI

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Apple Arcade gets 'Pusheen's Place,' 'Terraria+,' and more in October

Apple Arcade is adding five games in October, led by Pusheen's first officially licensed game, "River City Survivors," and "Terraria+."

Colorful cartoon scene of Pusheen and friends around a pastel house, trees, picnic, and street, with balloons, treats, playful animals, and a rainbow arcing across a bright sky
'Pusheen's Place' comes to Apple Arcade this October

October will give Apple Arcade a minor bump in its gaming catalog. This time, however, it offers three heavy hitters.


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