Naomi Misora (Death Note): Former FBI agent investigating the death of her fiancé. She is the first to correctly deduce that Kira is able to control his victims. But she just so happens to meet Light at the wrong time and is killed despite being completely and utterly innocent. She was not his first innocent victim, but she serves as the first character whose death comes with the gravity of the situation reflected in their scene. It highlights the evil of Light Yagami very well.

Drew Sharp (Breaking Bad): Teenager on a dirt bike who happens to witness Walt's crew return from the Heist. Despite the child not having understood anything, he is shot and killed immediately. To the average viewer, just the heist and everything prior would be enough to deduce the wrongs of the crew but this death really bashes the point in your head that Walt's rise inevitably kills innocents.